Mariano Maffei

This paper describes a method to selectively photoablate nociceptors in mice using a modified NGF ligand and NIR light, reducing pain behaviors in multiple pain models.

This study identifies TrkB-expressing sensory neurons as key to mechanical allodynia and demonstrates their ablation as a treatment for neuropathic pain.

This paper develops a molecule-guided laser ablation strategy to control itch by targeting itch-sensing neurons in mouse models of skin diseases.