Emerald Perlas

The transcription of a single olfactory receptor per neuron is enforced by epigenetic silencing of their enhancers

This study identifies TRIM66 as a key factor enforcing monogenic expression of olfactory receptors through epigenetic silencing of super-enhancers, impacting axonal projections and behavior.

Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy

This study uses base editors and AAVMYO to correct Rbm20 mutations in cardiomyocytes, improving splicing and cardiac function in mouse models of dilated cardiomyopathy.

The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart

This study identifies pCharme, a lncRNA that regulates cardiomyocyte maturation by forming nuclear condensates and controlling cardiac development in mice.

Induction of flight via midbrain projections to thecuneiform nucleus

The paper identifies midbrain projections to the cuneiform nucleus that induce flight behavior through optogenetic stimulation.

NGF-mediated photoablation of nociceptors reduces pain behavior in mice

This paper describes a method to selectively photoablate nociceptors in mice using a modified NGF ligand and NIR light, reducing pain behaviors in multiple pain models.

Control of mechanical pain hypersensitivity through ligand-targeted photoablation of TrkB positive sensory neurons

This study identifies TrkB-expressing sensory neurons as key to mechanical allodynia and demonstrates their ablation as a treatment for neuropathic pain.

Molecule guided laser ablation as a novel therapeutic strategy to control itch.

This paper develops a molecule-guided laser ablation strategy to control itch by targeting itch-sensing neurons in mouse models of skin diseases.