Emilia Puig Lombardi

This study uses multiomic analysis to identify IFN signaling as a key driver in Hailey-Hailey disease and shows that ruxolitinib treatment reduces inflammation and improves patient outcomes.

The paper introduces a spatial multi-omics approach combining protein and transcriptome analysis to characterize human cancer tissue from a single section, revealing immune phenotypes and cellular states.

The paper re-analyzes scRNA-seq datasets to show that luminal progenitor clusters across studies overlap and matches FACS-enriched LSCmed cells in mice and humans.

The paper maps replication origin firing and fork progression within TAD boundaries, showing their relationship with CTCF, cohesin, and replication timing.

The paper shows that G-quadruplexes bind heme in vitro and that displacing heme from quadruplexes increases heme degradation gene expression in human cells.