Author

Charlotte Hewel

Johannes Gutenberg University MainzORCID 0000-0003-0967-0054Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1 Research Focus:eQTL / molecular QTL mapping· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

David RosenkranziD· 2 shared Susanne GerberiD· 2 shared Alexandra RussoiD· 1 shared Anna WierczeikoiD· 1 shared Benjamin Ottum· 1 shared Daniel GebertiD· 1 shared David Fournier· 1 shared Edward A. LemkeiD· 1 shared

Activity by Year

2017-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersMolecular Biology

David RosenkranzORCID

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4 papers

Recent·Most cited

BioinformaticsNucleic Acids ResearchPeer-reviewedNov 5, 2025

Direct RNA sequencing (RNA004) allows for improved transcriptome assessment and near real-time tracking of methylation for medical applications

Charlotte Hewel, Anna Wierczeiko, Johannes Miedema…·Susanne Gerber

This study evaluates improvements in direct RNA sequencing (DRS) using RNA004 chemistry and modified-base-calling models, showing enhanced throughput, accuracy, and detection of RNA modifications in clinical applications.

42 citationstop 1%

humanlong-read sequencing

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Molecular BiologyRNAPeer-reviewedMar 6, 2020

5’ tRNA halves are highly expressed in the primate hippocampus and sequence-specifically regulate gene expression

Julia Jehn, Jana Treml, Svenja Wulsch…·David Rosenkranz

The paper identifies high expression of 5' tRNA halves in primate hippocampus and shows they regulate gene expression through sequence-specific mechanisms.

47 citations

humanbulk RNA-seq

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BioinformaticsbioRxivPreprintJan 30, 2018

Imputation of posterior linkage probability relations reveals a significant influence of structural 3D constraints on linkage disequilibrium

Susanne Gerber, David Fournier, Charlotte Hewel, Illia Horenko

The paper introduces a new relation measure, Linkage Probability, to analyze genetic data and reveals 3D chromatin loop effects in SNP data.

2 citations

humanGWAS summary statistics

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BioinformaticsBMC GenomicsPeer-reviewedAug 22, 2017

unitas: the universal tool for annotation of small RNAs

Daniel Gebert, Charlotte Hewel, David Rosenkranz

unitas provides a comprehensive tool for small RNA annotation, supporting over 800 species and outperforming existing tools in accuracy and ease of use.

129 citations

multiple speciesstatistical model

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