Johannes Miedema

DModE provides an end-to-end framework for analyzing Nanopore DRS data, enabling integrated differential expression and modification analysis with automated reporting.

This study evaluates improvements in direct RNA sequencing (DRS) using RNA004 chemistry and modified-base-calling models, showing enhanced throughput, accuracy, and detection of RNA modifications in clinical applications.

ModiDeC is a deep-learning classifier that identifies multiple RNA modifications from direct nanopore sequencing, validated on synthetic data and biological samples.

This study identifies Dusp6 as a key inhibitor of oligodendrocyte plasticity after spinal cord injury and shows that its inactivation promotes axonal regrowth by converting oligodendrocytes into repair cells.