Michelle L. Delco

This study shows that loss of Cx43 in cartilage leads to mitochondrial dysfunction and accelerates post-traumatic osteoarthritis progression in a sex-specific manner.

This study shows that Cx43 and its isoform GJA1-20k facilitate mitochondrial transfer from mesenchymal stromal cells to chondrocytes, particularly under oxidative stress, suggesting potential therapeutic applications for osteoarthritis.