Author

Rajni Sharma

Northwestern UniversityORCID 0000-0003-1009-4154Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Edward Benjamin ThorpiD· 2 shared Gabriella S. Borkowski· 2 shared Navdeep S. ChandeliD· 2 shared Pinelopi P. KapitsinouiD· 2 shared Ratnakar TiwariiD· 2 shared Si Young AniD· 2 shared Susan E. QuagginiD· 2 shared Yalu Zhou· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Edward Benjamin ThorpORCID

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2 papers

Recent·Most cited

Molecular BiologyKidney InternationalPeer-reviewedFeb 14, 2026

Endothelial Prolyl Hydroxylase 3 Mitigates Maladaptive Inflammation to Promote Post-Ischemic Kidney Repair

Rajni Sharma, Ratnakar Tiwari, Yalu Zhou…·Pinelopi P. Kapitsinou

This study identifies endothelial PHD3 as a regulator of kidney repair after ischemia, showing its role in suppressing inflammation and fibrosis through HIF-dependent mechanisms.

1 citation

mousebulk RNA-seq

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Molecular BiologyJournal of Clinical InvestigationPeer-reviewedDec 2, 2024

Post-ischemic inactivation of HIF prolyl hydroxylases in endothelium promotes maladaptive kidney repair by inducing glycolysis

Ratnakar Tiwari, Rajni Sharma, Ganeshkumar Rajendran…·Pinelopi P. Kapitsinou

This study shows that inactivating PHD enzymes in endothelial cells after ischemic kidney injury promotes maladaptive repair through glycolysis and MCT4, which can be reversed by MCT4 inhibitors.

28 citationstop 2%

mousehuman

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