Intratumoural oncolytic HSV-1 reshapes the local and systemic immune landscape through CD8+ T cell reprogramming
Elizabeth S. Appleton, Anton Patrikeev, Victoria Roulstone, Mikel Portillo, Jehanne Hassan, Shane Foo, Lisa Hubbard, Joan Kyula, Isaac Dean, Ernesto López, Charleen Chan Wah Hak, Malin Pedersen, Antonio Rullan, Chanidapa Adele Tye, Mark Allen, , Alan A. Melcher
This paper shows that intratumoural oncolytic HSV-1 reprograms systemic immunity by inducing specific CD8 T cell populations that correlate with clinical response to immunotherapy.
bioRxiv · May 29, 2026 · PreprintCancer Biology