Daniel J. Friedman

This study examines how interictal epileptiform discharges (IEDs) affect memory during encoding and retrieval, finding they reduce memory success and disrupt hippocampal ripples.

In nine epilepsy patients, cortical activity carries next-word information up to 800 ms before onset, tracks GPT-2 surprise after onset, and fits GPT-2 contextual embeddings better than static ones.

The paper compares proteomic and transcriptomic profiles of hippocampus and cortex in SUDEP and high-risk SUDEP cases, finding no proteomic differences but 55 differentially expressed genes in hippocampus.

The paper demonstrates that chronic ambulatory intracranial EEG can measure hippocampal activity during associative memory tasks in patients with epilepsy.

The paper identifies replay of waking cortical activity patterns during slow-wave sleep in humans and links them to sleep features like spindles and sharp-wave ripples, supporting memory consolidation theories.