Author

James Dominic Mills

Amsterdam NeuroscienceORCID 0000-0002-9910-2933Unclaimed ORCID profile · follow to get notified of new preprints

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1 Approach:experimental assay· 1

Frequent Co-Authors

Eleonora AronicaiD· 4 shared Jasper J. AninkiD· 3 shared Maria ThomiD· 2 shared Alexander HaglundiD· 1 shared Alexi NottiD· 1 shared Alyma Somani· 1 shared Amy M. SmithiD· 1 shared Angelika MühlebneriD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersNeuroscience

Eleonora AronicaORCID

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4 papers

Recent·Most cited

Single-cell Mendelian randomisation identifies cell-type specific genetic effects on human brain disease and behaviour

Alexander Haglund, Verena Zuber, Maya Abouzeid, Yifei Yang, Jeong Hun Ko, Liv Wiemann, Maria Otero‐Jimenez, Louwai Muhammed, Rahel Feleke, Alexi Nott, James Dominic Mills, Liisi Laaniste, Djordje O. Gveric, Daniel Clode, Ann C. Babtie, , Michael R. Johnson

The paper uses single-cell Mendelian randomisation to identify cell-type specific genetic effects on brain disease and behaviour, revealing 118 genes with causal associations to 16 brain phenotypes.

Nature Genetics · Jan 10, 2025Peer-reviewedNeuroscience

Single-cell profiling of cortical tubers in tuberous sclerosis complex shows molecular structure preservation and massive reorganization of metabolism

Frederik N. F. Sørensen, Tin Luka Petanjek, Mirte Scheper, Rasmus Rydbirk, Irina Korshunova, Jasper J. Anink, Angelika Mühlebner, James Dominic Mills, Zdravko Petanjek, Eleonora Aronica, Konstantin V. Khodosevich

The paper uses single-nucleus RNA sequencing to analyze cortical tubers in TSC, finding preserved neuronal subtypes and metabolic reorganization in neurons.

bioRxiv · Oct 31, 2024 · PreprintNeuroscience

Proteomic and Transcriptomic Analyses of the Hippocampus and Cortex in SUDEP and High-Risk SUDEP Cases

Dominique Leitner, James Dominic Mills, Geoffrey Pires, Arline Faustin, Eleanor Drummond, Evgeny Kanshin, Shruti Nayak, Manor Askenazi, Chloe Verducci, Bei Jun Chen, Michael Janitz, Jasper J. Anink, Johannes C. Baayen, Sander Idema, Erwin Alexander van Vliet, , Orrin Devinsky

The paper compares proteomic and transcriptomic profiles of hippocampus and cortex in SUDEP and high-risk SUDEP cases, finding no proteomic differences but 55 differentially expressed genes in hippocampus.

bioRxiv · Jul 27, 2020 · PreprintNeuroscience

A novel Ataxin-3 knock-in mouse model mimics the human SCA3 disease phenotype including neuropathological, behavioral, and transcriptional abnormalities

Eva Haas, Rana Dilara Incebacak Eltemur, Thomas Hentrich, Yacine Maringer, Thorsten Schmidt, Frank Zimmermann, Nicolas Casadei, James Dominic Mills, Eleonora Aronica, Olaf Rieß, Julia Maria Schulze-Hentrich, Jeannette Hübener‐Schmid

This paper describes a novel Ataxin-3 knock-in mouse model that replicates key neuropathological, behavioral, and transcriptional features of human SCA3 disease.

bioRxiv · Feb 28, 2020 · PreprintNeuroscience