Filippo Rosselli

The paper identifies new protein interactions of FANCA, revealing its roles in mRNA processes beyond DNA repair, and suggests potential therapeutic targets for Fanconi anemia.

The paper shows that ATR and DDK control TopBP1-mediated locking of dormant origins at the pre-IC stage, with compensation involving both passive and active processes.

This study shows that Fanconi anemia proteins are essential for maintaining nucleolar homeostasis, with loss-of-function leading to nucleolar DNA damage, rDNA rearrangements, and impaired ribosome biogenesis.