Angelos Constantinou

This study identifies Treacle and NBS1 as components of TOPBP1 condensates that activate ATM signaling and show their cooperative role in organizing DNA damage responses.

This study identifies TopBP1 condensation inhibitors, showing AZD2858 disrupts ATR signaling and synergizes with chemotherapy in colorectal cancer.

The paper identifies new protein interactions of FANCA, revealing its roles in mRNA processes beyond DNA repair, and suggests potential therapeutic targets for Fanconi anemia.

The paper shows KIF2C forms condensates during mitosis that concentrate PLK1 and phosphorylated BRCA2 at kinetochore microtubules, enhancing their kinase activity and attachment stability.

This study identifies GNL3 as a protein that prevents DNA resection at stalled replication forks, highlighting its role in protecting the genome from damage during replication stress.