Author

Michelle Debatisse

Centre National de la Recherche ScientifiqueORCID 0000-0002-7113-3965Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:DNA methylation· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 2 Organism:mouse· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:differential expression· 1

Frequent Co-Authors

Caroline BrossasiD· 2 shared Chun-Long CheniD· 2 shared Marie‐Noëlle PrioleauiD· 2 shared Mélanie Schmidt· 2 shared Olivier Brison· 2 shared Sami El-HilaliiD· 2 shared Stéphane KoundrioukoffiD· 2 shared Viola NähseiD· 2 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersMolecular Biology

Caroline BrossasORCID

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4 papers

Recent·Most cited

Transcription Represses Origin Activity in a Late-Replicating Fragile Site

Juliette Mandelbrojt, Caroline Brossas, Amara Masson, Théo Baret, Michelle Debatisse, Marie‐Noëlle Prioleau

This study shows that transcription represses replication origin activity in late-replicating regions, leading to fragile site formation.

bioRxiv · Aug 1, 2025 · PreprintMolecular Biology

The balance between ATR and DDK activities controls TopBP1-mediated locking of dormant origins at the pre-IC stage

Stéphane Koundrioukoff, Su-Jung Kim, Nathan Alary, Antoine Toffano, Rodrigo Meléndez García, Xia Wu, Yaqun Liu, Stefano Gnan, Sami El-Hilali, Olivier Brison, Filippo Rosselli, Chun-Long Chen, Michelle Debatisse

The paper shows that ATR and DDK control TopBP1-mediated locking of dormant origins at the pre-IC stage, with compensation involving both passive and active processes.

bioRxiv · Nov 29, 2023 · PreprintGenetics

TRANSCRIPTION-MEDIATED ORGANIZATION OF THE REPLICATION INITIATION PROGRAM ACROSS LARGE GENES SETS UP COMMON FRAGILE SITES GENOME-WIDE

Olivier Brison, Sami El-Hilali, Dana Azar, Stéphane Koundrioukoff, Mélanie Schmidt, Viola Nähse, Yan Jaszczyszyn, Anne-Marie Lachagès, Bernard Dutrillaux, Claude Thermes, Michelle Debatisse, Chun-Long Chen

The paper shows that transcription suppresses replication initiation in large genes, leading to delayed replication and instability at common fragile sites.

Nature Communications · Dec 13, 2019Peer-reviewedGenomics

Transcription-dependent regulation of replication dynamics modulates genome stability

Marion Blin, Benoît Le Tallec, Viola Nähse, Mélanie Schmidt, Caroline Brossas, Gaël A. Millot, Marie‐Noëlle Prioleau, Michelle Debatisse

The paper investigates how transcription affects replication dynamics and genome stability in large genes, finding that moderate transcription increases instability while high transcription reduces it.

Nature Structural & Molecular Biology · Dec 20, 2018Peer-reviewedMolecular Biology