Michael H. Farkas

This study identifies differentially expressed genes and allele-specific expression in macular tissues across AMD stages, highlighting the RPE/choroid's role in disease pathophysiology.

This paper presents a comprehensive single-cell multi-omics atlas of the human retina, integrating RNA-seq and ATAC-seq data to identify cell-type-specific cis-element-gene relationships and transcription factor regulons.

The paper maps lncRNA subcellular localization in human RPE under normal and oxidative stress conditions, finding increased compartmentalization under stress.

The paper investigates how oxidative stress affects transcript localization in retinal pigment epithelium cells using RNA sequencing.

The paper generates patient-specific retinal organoids and RPE from RP type 11 patients to show PRPF31 mutations cause retinal-specific splicing defects and structural/functional impairments, which are corrected by in situ gene editing.