Jun Wang

Cross-Species Efficacy of Combinatorial Gene Therapy for Osteoarthritis and Correction of Neuro-Inflammatory Pain Mechanisms

A combinatorial gene therapy targeting inflammation and chondrocyte health slows OA progression and reduces pain in murine and equine models.

An Integrated Multi-omics Single Cell Atlas of the Human RPE and Choroid

The paper constructs a multi-omics single-cell atlas of human RPE and choroid, identifying cell types, aging patterns, and genetic risk factors for AMD.

An Integrated muti-omics cell atlas of the human trabecular meshwork and ciliary body

The paper creates a multi-omics atlas of human trabecular meshwork and ciliary body cells, identifying cell types and regulatory programs linked to glaucoma.

Genome-wide association and multi-omics functional screens reveal the genetic architecture of foveal development

This paper identifies genetic variants and genes associated with foveal hypoplasia using GWAS and multi-omics data, and establishes a zebrafish model to study the condition.

Genomic Insights into Hybridization and Speciation of Mitten Crabs in the Eriocheir Genus

The paper analyzes whole genome data from seven Eriocheir populations to reveal hybridization history and genomic adaptations in mitten crabs, identifying divergent selection and selective sweeps in reproductive genes.

Integrating short-read and long-read single-cell RNA sequencing for comprehensive transcriptome profiling in mouse retina

The paper compares short-read and long-read single-cell RNA sequencing in mouse retina, identifying 44,325 transcript isoforms, 38% previously uncharacterized.

The RNA-binding protein RSRC2 promotes mitotic fidelity by interacting with the lncRNA C1QTNF1-AS1

This study identifies RSRC2 as a regulator of mitotic fidelity through its interaction with the lncRNA C1QTNF1-AS1, showing defects in chromosome congression when either is lost.

Integrated multi-omics single cell atlas of the human retina

The paper creates a comprehensive human retina cell atlas using single-cell multi-omics data, revealing over 110 cell types and their gene regulatory networks, and enables fine-mapping of GWAS and eQTL variants.

A multi-omics atlas of the human retina at single-cell resolution

This paper presents a comprehensive single-cell multi-omics atlas of the human retina, integrating RNA-seq and ATAC-seq data to identify cell-type-specific cis-element-gene relationships and transcription factor regulons.

Monopogen: single nucleotide variant calling from single cell sequencing

Monopogen calls single nucleotide variants from single-cell sequencing data, achieving high accuracy in germline variant detection and enabling ancestry inference and variant association analysis.

Integrative single cell multiomics analysis of human retina indicates a role for hierarchical transcription factors collaboration in genetic effects on gene regulation

The paper identifies cell type-specific genetic effects on gene regulation in human retina using single-cell multiomics data and finds that trans-factors, not cis-elements, drive these effects.

Tissue-expression profiles unveils the gene interaction of hepatopancreas, eyestalk, and ovary in precocious female Chinese mitten crab, Eriocheir sinensis

The paper identifies gene interactions in hepatopancreas, eyestalk, and ovary tissues of precocious female Chinese mitten crabs, revealing their roles in vitellogenesis and sexual development.

GRIPT: A novel case-control analysis method for Mendelian disease gene discovery

GRIPT is a case-control analysis method for NGS data that improves disease gene discovery, particularly in highly heterogeneous Mendelian diseases.