Nicoletta Kessaris

The paper demonstrates that Chiari II brain malformation arises secondary to open spina bifida in mice, showing structural brain and skull defects linked to neurogenesis and neuronal migration disturbances.

This study shows that a specific PTEN mutation causes macrocephaly, lymphoid overgrowth, and late-onset cancer in mice by impairing nuclear PTEN functions, while maintaining normal PI3K/AKT signaling.

The paper uses single-cell transcriptomics to analyze hippocampal CA1 inhibitory neurons, revealing both discrete classes and continuous variation in their diversity.

The paper uses scRNA-seq to classify CA1 interneurons into a 5-level hierarchy, identifies novel molecular markers, and discovers a new interneuron population called R2C2 cells.