Lorenza Magno

The hypermorphic PLCγ2 S707Y variant dysregulates microglial cell function: insight into PLCγ2 activation in brain health and disease, and opportunities for therapeutic modulation.

This study investigates the effects of the PLCγ2 S707Y hypermorphic variant on human microglia, showing increased enzymatic activity but reduced phagocytosis and cytokine production, and suggests therapeutic strategies should mimic the beneficial effects of the P522R variant.

A primary rodent triculture model to investigate the role of glia-neuron crosstalk in regulation of neuronal activity.

This paper develops a triculture model of neurons, astrocytes, and microglia to study glia-neuron interactions and their impact on neuronal activity and synapse function.

Alzheimer’s disease Phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph

The paper confirms that the PLCG2 P522R variant is protective against Alzheimer’s disease and shows it weakly activates PLCG2 enzyme function in microglia.

Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics

The paper uses single-cell transcriptomics to analyze hippocampal CA1 inhibitory neurons, revealing both discrete classes and continuous variation in their diversity.

Molecular organization of CA1 interneuron classes

The paper uses scRNA-seq to classify CA1 interneurons into a 5-level hierarchy, identifies novel molecular markers, and discovers a new interneuron population called R2C2 cells.