The paper demonstrates that Chiari II brain malformation arises secondary to open spina bifida in mice, showing structural brain and skull defects linked to neurogenesis and neuronal migration disturbances.

Disease Models & Mechanisms · Mar 18, 2026Peer-reviewedDevelopmental Biology

DRAXIN regulates interhemispheric fissure remodelling to influence the extent of corpus callosum formation

Laura R. Morcom, Timothy J. C. Edwards, Eric Rider, Dorothy M. Jones, Jonathan W. C. Lim, Kok‐Siong Chen, Ryan J. Dean, Jens Bunt, Yunan Ye, Ilan Gobius, Rodrigo Suárez, Simone Alyson Mandelstam, Elliott H. Sherr, Linda J. Richards

The paper identifies incomplete interhemispheric fissure remodelling as a key factor in corpus callosum dysgenesis, linking genetic and cellular factors to variable phenotypes in mice and humans.

eLife · May 4, 2021Peer-reviewedNeuroscience

The DCC receptor regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation

Laura R. Morcom, Ilan Gobius, Ashley P.L. Marsh, Rodrigo Suárez, Jonathan W. C. Lim, Caitlin R. Bridges, Yunan Ye, Laura R. Fenlon, Yvrick Zagar, Amelia M Douglass, Amber-Lee S. Donahoo, Thomas Fothergill, Samreen Shaikh, Peter Kozulin, Timothy J. C. Edwards, , Linda J. Richards

This study shows that DCC and NTN1 regulate astroglial development and interhemispheric fissure remodeling, essential for corpus callosum and hippocampal commissure formation.

eLife · Apr 19, 2021Peer-reviewedNeuroscience