Author

Jelmer Legebeke

University of SouthamptonORCID 0000-0003-1194-8959Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Gabrielle WhewayiD· 3 shared Diana BaralleiD· 2 shared Jane S. LucasiD· 2 shared Jenny LordiD· 2 shared Liliya NazlamovaiD· 2 shared Paul J. S. SkippiD· 2 shared Aaron Ions GardneriD· 1 shared Adnan AzimiD· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Gabrielle WhewayORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintMay 12, 2021

Distinct immune responses in patients infected with influenza or SARS-CoV-2, and in COVID-19 survivors, characterised by transcriptomic and cellular abundance differences in blood.

Jelmer Legebeke, Jenny Lord, Rebekah Penrice-Randal…·Diana Baralle

The paper compares immune responses in influenza and SARS-CoV-2 infected patients and COVID-19 survivors using transcriptomic data, identifying distinct immune signatures and prognostic indicators.

1 citation

humanbulk RNA-seq

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Molecular BiologyNature GeneticsPeer-reviewedJan 11, 2021

A novel isoform of ACE2 is expressed in human nasal and bronchial respiratory epithelia and is upregulated in response to RNA respiratory virus infection

Cornelia Blume, Claire L. Jackson, Cosma Mirella Spalluto…·Vito Mennella

The paper identifies a novel short ACE2 isoform expressed in respiratory epithelia that is upregulated by interferon and RNA virus infection but not SARS-CoV-2, and shows reduced SARS-CoV-2 binding affinity.

180 citationstop 1%

human

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Genetic & Genomic MedicineHuman GeneticsPeer-reviewedOct 23, 2020

High-throughput PRPF31 variant characterisation pipeline consistent with ACMG/AMP clinical variant interpretation guidelines

Liliya Nazlamova, Nicholas Simon Thomas, Man‐Kim Cheung…·Gabrielle Wheway

This paper presents a high-throughput imaging assay for characterizing PRPF31 missense variants using CRISPR-edited cells, providing evidence for variant classification.

9 citations

humanexperimental assay

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