Author

Jane S. Lucas

University Hospital Southampton NHS Foundation TrustORCID 0000-0001-8701-9975Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:statistical model· 1

Frequent Co-Authors

Diana BaralleiD· 2 shared Gabrielle WhewayiD· 2 shared Jelmer LegebekeiD· 2 shared Paul J. S. SkippiD· 2 shared Aaron Ions GardneriD· 1 shared Adnan AzimiD· 1 shared Andrés F. VallejoiD· 1 shared Anthony Peter WilliamsiD· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Diana BaralleORCID

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2 papers

Recent·Most cited

Distinct immune responses in patients infected with influenza or SARS-CoV-2, and in COVID-19 survivors, characterised by transcriptomic and cellular abundance differences in blood.

Jelmer Legebeke, Jenny Lord, Rebekah Penrice-Randal, Andrés F. Vallejo, Stephen Poole, Nathan James Brendish, Xiaofeng Dong, Catherine S. Hartley, John W. Holloway, Jane S. Lucas, Anthony Peter Williams, Gabrielle Wheway, Fabio Strazzeri, Aaron Ions Gardner, James P. R. Schofield, , Diana Baralle

The paper compares immune responses in influenza and SARS-CoV-2 infected patients and COVID-19 survivors using transcriptomic data, identifying distinct immune signatures and prognostic indicators.

medRxiv · May 12, 2021 · PreprintGenetic & Genomic Medicine

A novel isoform of ACE2 is expressed in human nasal and bronchial respiratory epithelia and is upregulated in response to RNA respiratory virus infection

Cornelia Blume, Claire L. Jackson, Cosma Mirella Spalluto, Jelmer Legebeke, Liliya Nazlamova, Franco Conforti, Jeanne‐Marie Perotin, Martin Frank, John Butler, Max Crispin, Janice L. Coles, James Thompson, Robert A. Ridley, Lareb S. N. Dean, Matthew Loxham, , Vito Mennella

The paper identifies a novel short ACE2 isoform expressed in respiratory epithelia that is upregulated by interferon and RNA virus infection but not SARS-CoV-2, and shows reduced SARS-CoV-2 binding affinity.

Nature Genetics · Jan 11, 2021Peer-reviewedMolecular Biology