Rebekah Penrice-Randal

The proteasome and ERAD pathways can regulate hepatitis E virus pORF1 proteostasis and genome replication

This study identifies the ERAD and proteasome pathways as regulators of HEV pORF1 proteostasis and genome replication.

The biodistribution and effect of post-exposure neutralising monoclonal antibody treatment in a mouse model of SARS-CoV-2 infection with viral spread to the brain

This study investigates the biodistribution and effects of Ronapreve in a mouse model of SARS-CoV-2 infection, showing it does not reach the brain but reduces viral loads in the lung and brain.

Efficient plasmid-based rescue of T7 RNA polymerase-driven calicivirus reverse genetics systems in mammalian cells using vaccinia virus RNA capping enzymes

This paper introduces a plasmid-based system using vaccinia virus capping enzymes to enhance calicivirus reverse genetics in mammalian cells, significantly increasing viral titres and polyprotein abundance.

Hypoxia inducible factors regulate Pneumovirus replication by enhancing innate immune sensing

This study shows that HIF activation limits pneumovirus replication by enhancing innate immune sensing and reducing viral RNA methylation.

The K18-hACE2 mouse model of SARS-CoV-2 infection to illustrate the role and response of the vasculature in neurotropic viral infection

This study uses a K18-hACE2 mouse model to show SARS-CoV-2 infects neurons in the brain without damaging blood vessels, leading to limited neuroinflammation.

Emerging variants of canine enteric coronavirus associated with seasonal outbreaks of severe canine gastroenteric disease

The paper identifies a new CECoV variant associated with seasonal outbreaks of severe canine gastroenteritis and shows its genetic relationship to a 2020 variant, but not to human respiratory-related CECoV-like viruses.

Amplicon and metagenomic analysis of MERS-CoV and the microbiome in patients with severe Middle East respiratory syndrome (MERS)

The paper develops an amplicon-based sequencing method for rapid MERS-CoV genotyping and evaluates it alongside metagenomic analysis to study the microbiome in MERS patients.

Distinct immune responses in patients infected with influenza or SARS-CoV-2, and in COVID-19 survivors, characterised by transcriptomic and cellular abundance differences in blood.

The paper compares immune responses in influenza and SARS-CoV-2 infected patients and COVID-19 survivors using transcriptomic data, identifying distinct immune signatures and prognostic indicators.