Desmond J. Smith

This paper compares two human genetic interaction maps generated using radiation hybrids and CRISPRi, showing they share some interactions but differ in gene pair specificity and GWAS network overlap.

The paper identifies genetic loci associated with saline self-administration in mice, finding distinct genetic bases compared to cocaine self-administration.

The paper identifies genetic loci and pathways associated with cocaine self-administration in mice using GWAS and TWAS, highlighting Trpv2 as a key gene.

The paper uses single-cell RNA sequencing to analyze gene expression changes in the substantia nigra pars compacta of pesticide-exposed mice, identifying differentially expressed genes and highlighting the role of support cells in pesticide-induced Parkinson's disease.

The paper develops a cost-effective method for mapping genetic interactions in mammalian cells using shallow sequencing of RH clones, demonstrating feasibility with a small dataset.

The paper uses pooled radiation hybrid analysis to identify loci affecting growth, drug response, and mitochondrial abundance in mammalian cells, finding high-resolution genetic effects and new insights into centromere function.

This paper explores using copy number alterations (CNAs) to construct networks that guide combinatorial therapy for cancer and other diseases by identifying gene interactions associated with survival mechanisms.