James David Jentsch

A shared genetic regulator of metabolism and addiction-related behavior in mice and humans

This study identifies a shared genetic regulator linking metabolism and addiction-related behavior in mice and humans through a common enhancer regulating Eed/Me3 and EED/ME3.

Behavioral variation across multiple phases of intravenous cocaine self-administration among genetically diverse mouse populations

The paper examines behavioral variation in cocaine self-administration across multiple phases in genetically diverse mouse populations, identifying strain and sex differences and extreme strains for drug intake traits.

Differing genetics of saline and cocaine self administration in the hybrid mouse diversity panel

The paper identifies genetic loci associated with saline self-administration in mice, finding distinct genetic bases compared to cocaine self-administration.

Neuron Navigator 1 Regulates Learning, Memory, and the Response to Multiple Potentially Addictive Drugs

This study identifies Nav1 as a gene regulating learning, memory, and responses to addictive drugs through synaptic balance changes in the cortex and hippocampus.

Genetic pathways regulating the longitudinal acquisition of cocaine self-administration in inbred and recombinant inbred mice

The paper identifies genetic loci and pathways associated with cocaine self-administration in mice using GWAS and TWAS, highlighting Trpv2 as a key gene.

The Collaborative Cross strains and their founders vary widely in cocaine-induced behavioral sensitization

The paper measures cocaine-induced behavioral sensitization across genetically diverse Collaborative Cross strains and their founders, identifying significant heritability and phenotypic variation.

Reversal Learning Phenotypes are Linked with Novel Genetic Loci in Diversity Outbred Mice

The paper identifies genetic loci associated with reversal learning phenotypes in Diversity Outbred mice, revealing a genome-wide significant QTL on chromosome 7.

Heritable variation in locomotion, reward sensitivity and impulsive behaviors in a genetically diverse inbred mouse panel

The paper examines heritability of reward sensitivity and impulsivity traits in inbred mice and finds these traits are independent and heritable.

Syn3 Gene Knockout Negatively Impacts Aspects of Reversal Learning Performance

This study shows that Syn3 gene knockout in mice impairs reversal learning performance, increasing perseverative behavior and reducing anticipatory responses during contingency reversal.

Heritability of ethanol consumption and pharmacokinetics in a genetically diverse panel of Collaborative Cross mouse strains and their inbred founders

This study examines heritability of ethanol consumption and pharmacokinetics in genetically diverse mouse strains, identifying heritable variation and sex-modulated genetic effects.

Consideration of genetic and sex effects in mice enhances consilience with human addiction studies.

This study shows that including genetic and sex differences in mice improves the alignment of addiction-related traits with human studies.

Genetic variation and gene expression across multiple tissues and developmental stages in a non-human primate

The paper generates a transcriptome resource and eQTL catalogue in vervet monkeys, revealing sex and age-related expression patterns and key regulatory loci.