Author

Alexandra Lum

University of California, Santa CruzORCID 0009-0006-9866-0163Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:Drosophila· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Jodie JacobsiD· 2 shared Jonas NykampiD· 2 shared Shelbi L. RusselliD· 2 shared Cade MirchandaniiD· 1 shared Cayla R. M. LagousisiD· 1 shared Merly EscalonaiD· 1 shared Richard Edward GreeniD· 1 shared Samuel SaccoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 31 mutual co-author links

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2 shared papersGenomics

Jodie JacobsORCID

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2 papers

Recent·Most cited

GenomicsbioRxivPreprintAug 4, 2026

Single-cell transcriptomics reveals a multiphasic Wolbachia host infection trajectory

Jodie Jacobs, Alexandra Lum, Jonas Nykamp…·Shelbi L. Russell

This study uses single-cell RNA sequencing to reveal how Wolbachia infection progresses through distinct transcriptional phases in Drosophila cells.

DOI 10.64898/2026.07.29.741357

DrosophilascRNA-seq

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Cell BiologybioRxivPreprintJun 5, 2025

Wolbachia infection induces host cell state changes in vitro and determines symbiotic fate in Drosophila

Jodie Jacobs, Jonas Nykamp, Alexandra Lum…·Shelbi L. Russell

This study shows Wolbachia infection changes host cell states in Drosophila cell lines, affecting gene expression and chromatin structure, and suggests these changes determine symbiotic outcomes.

1 citation

Drosophilabulk RNA-seq

𝕏 PostBluesky