GeneticsbioRxivPreprint
Promoter Or Enhancer Activation By CRISPRa Rescues Haploinsufficiency Caused Obesity
Navneet Kaur Matharu, Sawitree Rattanasopha, Lenka Maliskova…·Nadav Ahituv
This study shows CRISPRa can rescue Sim1 haploinsufficiency-induced obesity by targeting the promoter or enhancer, demonstrating tissue-specific upregulation of Sim1.
DOI 10.1101/140426