Christian Vaisse

This study shows that ciliary ARL13B in the nervous system is essential for body weight regulation in mice, as its disruption leads to obesity and metabolic dysfunction.

The paper investigates how physiological conditions like feeding, obesity, and circadian rhythm affect ciliary GPCR localization and cilia dynamics in the brain using MCHR1 and NPY2R as models.

The paper integrates single-cell RNA and ATAC-seq data from mouse and human hypothalamus to identify sex-specific genes and obesity-associated regulatory elements.

This study shows that MRAP2 is essential for MC4R's localization to primary cilia and its role in regulating energy homeostasis and body weight.

The paper maps genomic and epigenomic features of leptin-responsive hypothalamic neurons and identifies regulatory elements overlapping obesity-associated SNPs.

This study shows CRISPRa can rescue Sim1 haploinsufficiency-induced obesity by targeting the promoter or enhancer, demonstrating tissue-specific upregulation of Sim1.