GenomicsPLoS GeneticsPeer-reviewed
Functional assessment of the "two-hit" model for neurodevelopmental defects in Drosophila and X. laevis
Lucilla Pizzo, Micaela C. Lasser, Tanzeen Yusuff…·Santhosh Girirajan
The paper tests a 'two-hit' model for neurodevelopmental defects by examining interactions between 16p12.1 homologs and 'second-hit' genes in Drosophila and Xenopus laevis, finding genetic interactions in 63% of tested pairs.
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