Janani S. Iyer

Origin-1: a generative AI platform for de novo antibody design against novel epitopes

Origin-1 generates high-confidence, specific antibodies against zero-prior epitopes through generative AI, validated with biophysical assays and cryo-EM.

Functional assessment of the "two-hit" model for neurodevelopmental defects in Drosophila and X. laevis

The paper tests a 'two-hit' model for neurodevelopmental defects by examining interactions between 16p12.1 homologs and 'second-hit' genes in Drosophila and Xenopus laevis, finding genetic interactions in 63% of tested pairs.

Drosophila models of pathogenic copy-number variant genes show global and non-neuronal defects during development

The paper systematically analyzes non-neuronal defects in Drosophila models of pathogenic copy-number variant genes, identifying developmental issues in multiple tissues and signaling pathways.

NCBP2 modulates neurodevelopmental defects of the 3q29 deletion in Drosophila and X. laevis models

This study identifies NCBP2 as a key modifier gene in the 3q29 deletion, showing it enhances developmental defects through disrupted apoptosis and cell cycle mechanisms in Drosophila and Xenopus models.

Pervasive epistasis modulates neurodevelopmental defects of the autism-associated 16p11.2 deletion

The paper identifies genetic interactions within the 16p11.2 deletion that modulate neurodevelopmental phenotypes in Drosophila and links these interactions to human brain networks.