Author

Tanzeen Yusuff

Pennsylvania State UniversityORCID 0000-0002-5601-9208Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:Drosophila· 4 Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Organism:human· 1

Frequent Co-Authors

Janani S. IyeriD· 3 shared Lucilla PizzoiD· 3 shared Matthew JenseniD· 3 shared Santhosh GirirajaniD· 3 shared Sneha YennawariD· 3 shared Dagny J. Gould· 2 shared Emily HuberiD· 2 shared Inshya Desai· 2 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Janani S. IyerORCID

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Author profile →

4 papers

Recent·Most cited

Functional assessment of the "two-hit" model for neurodevelopmental defects in Drosophila and X. laevis

Lucilla Pizzo, Micaela C. Lasser, Tanzeen Yusuff, Matthew Jensen, Phoebe Ingraham, Emily Huber, Mayanglambam Dhruba Singh, Connor Monahan, Janani S. Iyer, Inshya Desai, Siddharth Karthikeyan, Dagny J. Gould, Sneha Yennawar, Alexis T. Weiner, Vijay Kumar Pounraja, , Santhosh Girirajan

The paper tests a 'two-hit' model for neurodevelopmental defects by examining interactions between 16p12.1 homologs and 'second-hit' genes in Drosophila and Xenopus laevis, finding genetic interactions in 63% of tested pairs.

PLoS Genetics · Apr 5, 2021Peer-reviewedGenomics

Drosophila models of pathogenic copy-number variant genes show global and non-neuronal defects during development

Tanzeen Yusuff, Matthew Jensen, Sneha Yennawar, Lucilla Pizzo, Siddharth Karthikeyan, Dagny J. Gould, Avik Sarker, Erika Gedvilaite, Yurika Matsui, Janani S. Iyer, Zhi-Chun Lai, Santhosh Girirajan

The paper systematically analyzes non-neuronal defects in Drosophila models of pathogenic copy-number variant genes, identifying developmental issues in multiple tissues and signaling pathways.

PLoS Genetics · Jun 24, 2020Peer-reviewedGenomics

NCBP2 modulates neurodevelopmental defects of the 3q29 deletion in Drosophila and X. laevis models

Mayanglambam Dhruba Singh, Matthew Jensen, Micaela C. Lasser, Emily Huber, Tanzeen Yusuff, Lucilla Pizzo, Brian Lifschutz, Inshya Desai, Alexis Kubina, Sneha Yennawar, Sydney Kim, Janani S. Iyer, Diego E. Rincón-Limas, Laura Anne Lowery, Santhosh Girirajan

This study identifies NCBP2 as a key modifier gene in the 3q29 deletion, showing it enhances developmental defects through disrupted apoptosis and cell cycle mechanisms in Drosophila and Xenopus models.

bioRxiv · Dec 4, 2019 · PreprintGenomics

Codon-optimized TDP-43-mediated neurodegeneration in a Drosophila model for ALS/FTLD

Tanzeen Yusuff, Shreyasi Chatterjee, Ya‐Chu Chang, Tzu‐Kang Sang, George R. Jackson

This study creates a Drosophila model expressing codon-optimized human TDP-43, showing neurodegenerative phenotypes and toxic protein aggregation.

bioRxiv · Jul 10, 2019 · PreprintNeuroscience