Zhonghuai Hou

This study shows that HP1α phase separation is driven by interactions between intrinsically disordered regions and folded domains, not just IDRs alone, and reveals how poly-PR affects this process in a concentration-dependent manner.

This study identifies 28S rRNA as a key organizer of the tripartite nucleolus structure through multivalent interactions that drive the formation of the three-layered architecture.

This study identifies the temperature-dependent phase separation mechanism of HSF1, revealing its molecular basis and species-specific regulation through simulations and experiments.