Multivalent 28S rRNA Is the Organizer of the Nucleolus's Multi-layered Architecture
Jieli Wei, Yize Zhang, Jiaxin Wu, Bingcheng Ye, Xueyuan Fan, Yucen Hu, Zhonghuai Hou, ShengQi Xiang, Weirui Ma
This study identifies 28S rRNA as a key organizer of the tripartite nucleolus structure through multivalent interactions that drive the formation of the three-layered architecture.
Molecular Cell · Apr 1, 2026Peer-reviewedCell Biology