Cooperative IDR-folded domain interplay governs HP1α phase separation and underlies biphasic regulation by pathogenic poly-PR
Yize Zhang, Dan Su, Huanyu Li, Hongfeng Wang, Juan Li, Chaowei Shi, Tie Shen, Zhonghuai Hou, Zheng Ying, Shengqi Xiang
This study shows that HP1α phase separation is driven by interactions between intrinsically disordered regions and folded domains, not just IDRs alone, and reveals how poly-PR affects this process in a concentration-dependent manner.
bioRxiv · Oct 13, 2026 · PreprintBiochemistry