Nils Helge Schebb

This study shows that ex vivo supplementation of primary human macrophages with n-3 PUFAs increases phagocytosis, likely through reduced PGE2 levels rather than direct oxylipin effects.

This study develops a HILIC-based lipid fractionation method to directly quantify esterified oxylipins in plasma, revealing their lipid class binding preferences and dietary influences.

This paper designs and tests sEH-PROTACs to degrade soluble epoxide hydrolase, identifying PROTAC 23 as effective in degrading sEH in human macrophages.

This study shows that LPS differentially affects phagocytosis in M1- and M2-like macrophages via PGE2 and EP4 signaling, with NSAID inhibition increasing phagocytosis in M1-like macrophages.

This study shows that ex vivo DHA supplementation reduces prostaglandin E2 formation in human macrophages, suggesting a mechanism for n-3 PUFA's anti-inflammatory effects.