Author

Alexander I. Spira

Virginia Cancer SpecialistsORCID 0000-0003-1303-0447Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Aaliyah Washington· 1 shared Alberto VidesiD· 1 shared Antonio Cuevas-NavarroiD· 1 shared Aparna HegdeiD· 1 shared Arvin C. DariD· 1 shared Ben SangiD· 1 shared Brian Matthew WolpiniD· 1 shared David S. HongiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Aaliyah Washington

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1 paper

Recent·Most cited

Cancer BiologybioRxivPreprintApr 24, 2025

Mechanisms of resistance to active state selective tri-complex RAS inhibitors

Ben Sang, Ling Feng Ye, Feng Hu…·Piro Lito

This study identifies mechanisms of resistance to tri-complex RAS inhibitors in patients with RAS-driven cancers, showing that resistance alterations disrupt the RAS:drug:CYPA tri-complex formation.

12 citations

humanDNA methylation

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