Author

Aparna Hegde

Revolution Medicines (United States)ORCID 0000-0001-6616-4882Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Ignacio Garrido‐LagunaiD· 2 shared Aaliyah Washington· 1 shared Alberto VidesiD· 1 shared Alexander I. SpiraiD· 1 shared Amanda JiangiD· 1 shared Antonio Cuevas-NavarroiD· 1 shared Arvin C. DariD· 1 shared Ben SangiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

Ignacio Garrido‐LagunaORCID

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2 papers

Recent·Most cited

Cancer BiologyCancer ResearchPeer-reviewedMay 22, 2026

Genetic Drivers of Sensitivity or Resistance to RAS(ON) Multi-Selective Inhibitors in NRAS-Mutated Melanoma

Mona Foth, Wontak Kim, Kayla T. O’Toole…·Martin McMahon

This study identifies RAS(ON) inhibitors effective against NRAS-mutated melanoma and reveals resistance mechanisms through Ppia and Map2k1 mutations.

5 citationstop 1%

humanexperimental assay

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Cancer BiologybioRxivPreprintApr 24, 2025

Mechanisms of resistance to active state selective tri-complex RAS inhibitors

Ben Sang, Ling Feng Ye, Feng Hu…·Piro Lito

This study identifies mechanisms of resistance to tri-complex RAS inhibitors in patients with RAS-driven cancers, showing that resistance alterations disrupt the RAS:drug:CYPA tri-complex formation.

12 citations

humanDNA methylation

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