Mechanisms of resistance to active state selective tri-complex RAS inhibitors
Ben Sang, Ling Feng Ye, Feng Hu, Yasin Pourfarjam, Antonio Cuevas-Navarro, Shijie Fan, Zheng Qing Fu, Aaliyah Washington, Diego J. Rodriguez, Alberto Vides, Sumit Kar, Ethan Ahler, Kevin K. Lin, Aparna Hegde, Jacqueline A.M. Smith, , Piro Lito
This study identifies mechanisms of resistance to tri-complex RAS inhibitors in patients with RAS-driven cancers, showing that resistance alterations disrupt the RAS:drug:CYPA tri-complex formation.
bioRxiv · Apr 24, 2025 · PreprintCancer Biology