Cancer BiologybioRxivPreprint
Single cell multiomics reveal clonal and functional dynamics of MDS stem/progenitor cells during hypomethylating therapy
Julie A.I. Thoms, Henry R. Hampton, Priscilla Li Shan Boon…·John E. Pimanda
This study uses single-cell multiomics to show that AZA response in MDS involves hematopoietic regeneration from mutated HSPCs and that AZA-refractive sub-populations contribute to disease progression.