Author

Christopher J. Jolly

UNSW SydneyORCID 0000-0002-9307-1056Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

John E. PimandaiD· 4 shared Julie A.I. ThomsiD· 4 shared Feng YaniD· 3 shared Henry R. HamptoniD· 3 shared Mary N.T. NguyeniD· 3 shared Olivia J. StonehouseiD· 3 shared Xiaoheng ZouiD· 3 shared Elaheh Sadat Ghodousi· 2 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

John E. PimandaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cell-state-specific mechanisms of 5-azacytidine response in myelodysplastic neoplasms

Golam Sarower Bhuyan, Feng Yan, Mary N.T. Nguyen, Hoi Man Chung, Xiaoheng Zou, Veena Gullapalli, Lachlin Vaughan, Olivia J. Stonehouse, Henry R. Hampton, Shen Sylvie, Peter Truong, Ruchira Kumari DİSSANAYAKE, Elaheh Sadat Ghodousi, Swapna Joshi, Forrest C. Koch, , John E. Pimanda

The paper identifies cell-state-specific mechanisms of 5-azacytidine response in myelodysplastic neoplasms, showing distinct differentiation and transcriptional changes in cycling progenitors and quiescent stem cells.

bioRxiv · Jul 20, 2026 · PreprintCancer Biology

Azacitidine Response in Myelodysplastic Syndromes is Marked by NK-like CD8 T-Cell Expansion and CXCL12+ Reticular Cell Remodeling

Henry R. Hampton, Anne Pan, Michael J. Carnell, Bofei Wang, Diana Shinko, Maria A. Kasherman, Iveta Šlapetová, Swapna Joshi, Mary N.T. Nguyen, Feng Yan, Sarah Davidson, Nick F.Y. Choi, Jason W.H. Wong, Nicodemus T. Tedla, Devendra Hiwase, , John E. Pimanda

The paper identifies NK-like CD8 T-cell expansion and CXCL12+ reticular cell remodeling as markers of azacitidine response in MDS through longitudinal bone marrow profiling.

bioRxiv · Jul 8, 2026 · PreprintCancer Biology

Single cell multiomics reveal clonal and functional dynamics of MDS stem/progenitor cells during hypomethylating therapy

Julie A.I. Thoms, Henry R. Hampton, Priscilla Li Shan Boon, Olivia J. Stonehouse, Xiaoheng Zou, Hoi Man Chung, Forrest C. Koch, Feng Yan, Swapna Mahurkar Joshi, Mary N.T. Nguyen, Dorothy Hung, Dale Cameron Wright, Fatemeh Vafaee, Mark Niccolo Polizzotto, Alexander Swarbrick, , John E. Pimanda

This study uses single-cell multiomics to show that AZA response in MDS involves hematopoietic regeneration from mutated HSPCs and that AZA-refractive sub-populations contribute to disease progression.

bioRxiv · Mar 13, 2026 · PreprintCancer Biology

Genome-Wide CRISPR-Cas9 Screening Identifies a Synergy between Hypomethylating Agents and SUMOylation Blockade in MDS/AML

Peter Truong, Sylvie Shen, Swapna Mahurkar Joshi, Md Imtiazul Islam, Ling Zhong, Mark J. Raftery, Ali Afrasiabi, Hamid Alinejad‐Rokny, Mary T. H. D. Nguyen, Xiaoheng Zou, Golam Sarower Bhuyan, Chowdhury Hasan Sarowar, Elaheh Sadat Ghodousi, Olivia J. Stonehouse, Sara Mohamed, , John E. Pimanda

This study identifies a synergy between hypomethylating agents and SUMOylation blockade in MDS/AML using CRISPR-Cas9 screening, showing improved therapeutic outcomes in xenograft models.

bioRxiv · Apr 17, 2024 · PreprintMolecular Biology