Forrest C. Koch

Cell-state-specific mechanisms of 5-azacytidine response in myelodysplastic neoplasms

The paper identifies cell-state-specific mechanisms of 5-azacytidine response in myelodysplastic neoplasms, showing distinct differentiation and transcriptional changes in cycling progenitors and quiescent stem cells.

Single cell multiomics reveal clonal and functional dynamics of MDS stem/progenitor cells during hypomethylating therapy

This study uses single-cell multiomics to show that AZA response in MDS involves hematopoietic regeneration from mutated HSPCs and that AZA-refractive sub-populations contribute to disease progression.

Blastocoel fluid RNA predicts pregnancy outcome in assisted reproduction

The paper predicts pregnancy outcomes in assisted reproduction by analyzing RNA from blastocoel fluid, showing higher RNA levels correlate with implantation failure.

Cell Type-Specific Regulation by a Heptad of Transcription Factors in Human Hematopoietic Stem and Progenitor Cells

The paper identifies cell-type-specific regulatory roles of a heptad of transcription factors in human hematopoietic stem and progenitor cells.

Disentangling single-cell omics representation with a power spectral density-based feature extraction

This paper introduces scPSD, a pre-processing method that improves cell subtype separation in single-cell omics data by reducing complexity and enhancing cell-type discrimination.

Age- and sex-related topological organisation of human brain functional networks and their relationship to cognition

The paper examines age and sex effects on brain network topology in older adults and links these to cognitive performance using UK Biobank data.

Supervised Application of Internal Validation Measures to Benchmark Dimensionality Reduction Methods in scRNA-seq Data

This study benchmarks dimensionality reduction methods in scRNA-seq data using internal validation measures and DBSCAN, identifying LDA and PHATE as high-performing algorithms.

Novel genetic variants associated with brain functional networks in 18,445 adults from the UK Biobank

This study identifies genetic variants associated with brain functional network measures in UK Biobank participants, linking them to sleep and psychiatric traits.