Author

Laura Fahey

Ollscoil na Gaillimhe – University of GalwayORCID 0000-0003-1312-0071Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Bioinformatics· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Assay:GWAS summary statistics· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Research Focus:GWAS / association mapping· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Derek W. MorrisiD· 3 shared Pilib Ó BroiniD· 3 shared Gary J DonohoeiD· 2 shared Donna CosgroveiD· 1 shared Joan C. FitzgeraldiD· 1 shared Laura Whitton· 1 shared Laurena HolleraniD· 1 shared Lorna M. LopeziD· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 17 mutual co-author links

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3 shared papersGenomics

Derek W. MorrisORCID

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4 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintFeb 16, 2024

Pathway-based polygenic score analysis identifies the NRF2-KEAP1 and mRNA splicing - minor pathways as enriched in shared genetic variation between chronotype and bipolar disorder.

Laura Fahey, Lorna M. Lopez

DOI 10.1101/2024.02.16.24302920

humanGWAS summary statistics

𝕏 PostBluesky

BioinformaticsbioRxivPreprintJun 12, 2022

Comparing the XGBoost machine learning algorithm to polygenic scoring for the prediction of intelligence based on genotype data

Laura Fahey, Derek W. Morris, Pilib Ó Broin

This study compares XGBoost machine learning to polygenic scoring for predicting intelligence from genotype data, finding similar performance with fewer SNPs.

1 citation

GWAS summary statisticsmachine learning (classical)

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GenomicsGenesPeer-reviewedJan 10, 2022

Thirteen independent genetic loci associated with preserved processing speed in a study of cognitive resilience in 330,097 individuals in the UK Biobank

Joan C. Fitzgerald, Laura Fahey, Laurena Holleran…·Derek W. Morris

The paper identifies 13 genetic loci associated with cognitive resilience using GWAS-by-subtraction in UK Biobank data, showing enrichment in brain regions and cell types.

DOI 10.3390/genes13010122

humanGWAS summary statistics

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GenomicsHuman Molecular GeneticsPeer-reviewedSep 22, 2020

Genes influenced by MEF2C contribute to neurodevelopmental disease via gene expression changes that affect multiple types of cortical excitatory neurons

Donna Cosgrove, Laura Whitton, Laura Fahey…·Derek W. Morris

The paper identifies genes regulated by MEF2C during neurodevelopment that are associated with schizophrenia, intelligence, and neurodevelopmental disorders, with different genetic variants affecting distinct cell types and phenotypes.

32 citations

mousebulk RNA-seq

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