Author

Laurena Holleran

Ollscoil na Gaillimhe – University of GalwayORCID 0000-0002-8354-3670Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Genomics· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:GWAS / association mapping· 2 Assay:ChIP-seq· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Derek W. MorrisiD· 3 shared Gary J DonohoeiD· 3 shared Aodán LaighneachiD· 2 shared Declan Patrick McKernaniD· 2 shared John P. KellyiD· 2 shared Aaron L. GoldmaniD· 1 shared Aiden Peter CorviniD· 1 shared Allison E. Ashley‐KochiD· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersGenomics

Derek W. MorrisORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

GenomicsPLoS ONEPeer-reviewedDec 21, 2023

Social isolation-induced transcriptomic changes in mouse hippocampus impact the synapse and show convergence with human genetic risk for neurodevelopmental phenotypes

Aodán Laighneach, John P. Kelly, Lieve Desbonnet…·Derek W. Morris

This study identifies transcriptomic changes in mouse hippocampus due to social isolation and links them to human genetic risk factors for neurodevelopmental disorders.

5 citations

mousebulk RNA-seq

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GeneticsbioRxivPreprintDec 7, 2023

Direct targets of MEF2C are enriched for genes associated with schizophrenia and cognitive function and are involved in neurogenesis and mitochondrial function

Deema Ali, Aodán Laighneach, Emma Corley…·Derek W. Morris

The paper identifies MEF2C direct target genes enriched for schizophrenia and cognitive function genes, showing their involvement in neurogenesis and mitochondrial function.

DOI 10.1101/2023.12.07.570529

humanbulk RNA-seq

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GenomicsGenesPeer-reviewedJan 10, 2022

Thirteen independent genetic loci associated with preserved processing speed in a study of cognitive resilience in 330,097 individuals in the UK Biobank

Joan C. Fitzgerald, Laura Fahey, Laurena Holleran…·Derek W. Morris

The paper identifies 13 genetic loci associated with cognitive resilience using GWAS-by-subtraction in UK Biobank data, showing enrichment in brain regions and cell types.

DOI 10.3390/genes13010122

humanGWAS summary statistics

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GeneticsSciencePeer-reviewedMar 19, 2020

The genetic architecture of the human cerebral cortex

Katrina L. Grasby, Neda Jahanshad, Jodie N. Painter…·Yuri Milaneschi

The paper identifies genetic loci associated with human cortical structure and finds genetic correlations with neuropsychiatric disorders.

875 citationstop 1%

humanbulk RNA-seq

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