Chenghang Zhang

This study shows melanopsin regulates local axonal translation in developing ipRGCs, affecting circuit assembly and synaptic development before eye-opening.

The paper examines eye-specific differences in active zone addition during synaptic competition in the developing visual system, finding that dominant-eye projections form more multi-active-zone contacts while non-dominant-eye projections add single active zone synapses.

This study identifies the role of spontaneous activity in regulating presynaptic terminal remodeling during eye-specific synaptogenesis and competition in the mouse visual system.