Françis Lévi

The paper assesses the relationship between tumour circadian clock function and survival in breast cancer patients using a machine-learning model called TimeTeller, finding a negative association between clock function and survival.

TimeTeller estimates circadian clock function from single transcriptomes by modeling the multi-dimensional state of the clock, demonstrating its application across species and data types.

This paper develops a mathematical framework to optimize drug infusion pumps and analyze inter-patient pharmacokinetic variability for personalized cancer chronotherapy.