Denise F. Vlachou

High-throughput platforms for genetic perturbation screening using CRISPR/Cas9 in human iPSC-derived macrophages for drug discovery

The paper establishes a CRISPR/Cas9 screening platform in hiPSC-derived macrophages to identify genetic targets influencing inflammatory responses and functional phenotypes.

A robust negative association between estimated tumour circadian clock function and survival in early stage breast cancer

The paper assesses the relationship between tumour circadian clock function and survival in breast cancer patients using a machine-learning model called TimeTeller, finding a negative association between clock function and survival.

MALDI-TOF mass spectrometry and proteomics as phenotypic screening tools for anti-inflammatory drugs

This study evaluates two mass spectrometry-based phenotypic screening approaches for identifying anti-inflammatory compounds in macrophages and compares them to cytokine profiling.

TimeTeller: a tool to probe the circadian clock as a multigene dynamical system

TimeTeller estimates circadian clock function from single transcriptomes by modeling the multi-dimensional state of the clock, demonstrating its application across species and data types.