Susan Ingram

The paper shows that glucocorticoid-endocannabinoid interactions in the vlPAG promote pain resolution but require careful management to avoid receptor desensitization.

The paper identifies distinct neuron types in the vlPAG based on intrinsic firing patterns and shows that persistent inflammation selectively activates Phasic neurons, which are not defined by mu-opioid receptor expression.

This study shows that persistent inflammation reduces presynaptic CB1R function in rats but maintains eCB activation, with implications for pain therapy development.