BiophysicsbioRxiv
Lenacapavir-induced Lattice Hyperstabilization is Central to HIV-1 Capsid Failure at the Nuclear Pore Complex and in the Cytoplasm
Arpa Hudait, Ryan C. Burdick, Ellie K Bare…·Gregory A. Voth
This study investigates how lenacapavir affects HIV-1 capsid structure and nuclear entry by combining simulations and live-cell imaging, showing that it causes hyperstabilization and structural defects leading to capsid failure.