Author

Ryan C. Burdick

Frederick National Laboratory for Cancer ResearchORCID 0000-0002-0290-5896Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Vinay K. PathakiD· 3 shared Eric O. FreediD· 2 shared Alex B. KleinpeteriD· 1 shared Anna AlbeckaiD· 1 shared Arpa HudaitiD· 1 shared Boglarka VamosiD· 1 shared Brian T. LukeiD· 1 shared Donna L. MalleryiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersMicrobiology

Vinay K. PathakORCID

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3 papers

Recent·Most cited

The central pore of HIV-1 capsomers promotes sustained stability of the viral capsid

Alex B. Kleinpeter, Donna L. Mallery, Anna Albecka, Ryan C. Burdick, Nadine Renner, J. Ole Klarhof, Boglarka Vamos, Vinay K. Pathak, Leo C. James, Eric O. Freed

This study shows that the central pore of HIV-1 capsomers, mediated by R18 and K25 rings, is critical for capsid stability and post-entry events, with the N21K mutation compensating for R18 loss.

Journal of Molecular Biology · Jul 17, 2026Peer-reviewedMicrobiology

Elucidating the Mechanism by Which HIV-1 Nucleocapsid Mutations Confer Resistance to Integrase Strand Transfer Inhibitors

Yuta Hikichi, Ryan C. Burdick, Sean C. Patro, Si-Yuan Ding, Brian T. Luke, Erin Clark, Sherimay D. Ablan, Xiaolin Wu, Vinay K. Pathak, Eric O. Freed

The paper shows HIV-1 NC mutations accelerate viral DNA integration and reduce INSTI sensitivity, acting with IN mutations to confer resistance.

Science Advances · Sep 12, 2025Peer-reviewedMicrobiology

Lenacapavir-induced Lattice Hyperstabilization is Central to HIV-1 Capsid Failure at the Nuclear Pore Complex and in the Cytoplasm

Arpa Hudait, Ryan C. Burdick, Ellie K Bare, Vinay K. Pathak, Gregory A. Voth

This study investigates how lenacapavir affects HIV-1 capsid structure and nuclear entry by combining simulations and live-cell imaging, showing that it causes hyperstabilization and structural defects leading to capsid failure.

bioRxiv · Apr 18, 2025Biophysics