Arpa Hudait

This study uses coarse-grained models to simulate CPSF6 binding and oligomerization on HIV-1 capsid, revealing curvature-dependent interactions and their role in nuclear entry.

This study investigates how lenacapavir affects HIV-1 capsid structure and nuclear entry by combining simulations and live-cell imaging, showing that it causes hyperstabilization and structural defects leading to capsid failure.

This study shows IP6 binding influences the kinetic switch of the HIV-1 capsid's TVGG motif between coil and helix conformations, essential for pentamer formation.