SPP1hi macrophages in fibrin niches promote hyperplastic tissue remodeling in rheumatoid arthritis synovium
Ian Mantel, Haoxuan Zhang, Juan Vargas…·Thomas Eisenhaure
SPP1hi macrophages in RA synovial fibrin deposits promote tissue hyperplasia.
Author
Hospital for Special SurgeryORCID 0000-0003-1388-7002Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Ian Mantel, Haoxuan Zhang, Juan Vargas…·Thomas Eisenhaure
SPP1hi macrophages in RA synovial fibrin deposits promote tissue hyperplasia.
Jinsong Zhang, Jim Sindayen, Miyo Ota…·Laurent K. Verkoczy
This study identifies binding dynamics as a key factor in enhancing germinal center responses to HIV immunogens, improving the efficiency of somatic hypermutation and bnAb precursor activation.
Michael R. Mazzucco, Bella Y. Mehta, Jenelys Ruiz Ortiz…·Dana E. Orange
The paper identifies four synovial transcriptional clusters in knee OA linked to cartilage degeneration severity through bulk and single-cell RNA-seq analyses.
Preethi K. Periyakoil, Melanie H. Smith, Meghana Kshirsagar…·Christina S. Leslie
The paper uses spatial transcriptomics and a new method called DeepTopics to identify distinct cellular patterns in RA synovium, revealing divergent ectopic lymphoid structures.