Author

Michael R. Mazzucco

Hospital for Special SurgeryORCID 0000-0001-8443-7936Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Dana E. OrangeiD· 2 shared Accelerating Medicines Partnership: RA/SLE Network· 1 shared Anne‐Marie MalfaitiD· 1 shared Arin K. OestreichiD· 1 shared Bella Y. MehtaiD· 1 shared Bethany A. AndokoiD· 1 shared Bo ZhangiD· 1 shared Caryn R. HaleiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersPhysiology

Dana E. OrangeORCID

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2 papers

Recent·Most cited

PhysiologyOsteoarthritis and CartilagePeer-reviewedOct 1, 2026

Leptin Drives Osteoarthritis Pain Through Sensory Neuron Reprogramming Independent of Cartilage Signaling

Hope D. Welhaven, Elise K Truchan, Kristin L. Lenz…·Kelsey H. Collins

This study shows leptin drives OA pain via sensory neuron reprogramming, not cartilage signaling, by analyzing mouse models and human datasets.

DOI 10.1016/j.joca.2026.10.014

mousebulk RNA-seq

𝕏 PostBluesky

GenomicsbioRxivPreprintApr 24, 2026

Synovial transcriptional clusters link cartilage degeneration to cell-type-specific gene expression in knee osteoarthritis

Michael R. Mazzucco, Bella Y. Mehta, Jenelys Ruiz Ortiz…·Dana E. Orange

The paper identifies four synovial transcriptional clusters in knee OA linked to cartilage degeneration severity through bulk and single-cell RNA-seq analyses.

1 citation

humanbulk RNA-seq

𝕏 PostBluesky